As part of the conference "Pharmaceutical Science: Challenges and Solutions in the 21st Century," a session titled "Technological Priority: Drug Development and Manufacturing" was held, bringing together representatives of science, business, and young researchers. The moderators were Elena Flisyuk, Vice-Rector for Research at SPHFA of the Ministry of Health of Russia, Doctor of Pharmaceutical Sciences, Professor, and Alexander Shikov, Professor of the Department of Drug Technology at SPHFA, Doctor of Pharmaceutical Sciences, Associate Professor.
Opening the discussion, Alexey Yarutkin presented the development directions of the XV edition of the State Pharmacopoeia, emphasizing the role of standardization of dosage forms and excipients in ensuring drug quality. The topic was continued by Karen Sakanyan, who examined approaches to assessing the quality of pharmaceutical substances used as auxiliary components.
Practical aspects of manufacturing processes were revealed by Victor Kirilenko (Akademlab LLC), who noted the advantages of engaging independent organizations in validation and qualification: increased objectivity of assessment, reduced regulatory risks, and optimization of enterprise costs.
Promising technological media were the subject of Alexander Shikov's presentation, who introduced natural deep eutectic solvents as an environmentally safe alternative to traditional solvents. Despite a relatively short period of application, this direction is actively developing and opens up broad opportunities for further research.
Issues of controlled drug release were examined by Alexey Marchenko using alginate microcapsules as an example. The presented results showed the influence of technological parameters on shell structure and release profile, including successful models of probiotic microorganism encapsulation.
The experience of interaction between science and industry was presented by Sergey Belokurov, who described the development of urological dietary supplements in a "university – industrial partner – state" collaboration format. The importance of grant support as a tool for bringing developments to practical application was noted.
Modern approaches to active substance delivery were discussed in a report by Darya Gordeeva on intranasal systems for transporting drug substances to the brain. The theme of innovative carriers was continued by Ilya Sheferov, who presented research on transfersomal systems with 5-fluorouracil and cerium oxide nanoparticles.
Digital transformation of the industry was highlighted by Igor Simonenko, who presented a model of the digital architecture of pharmaceutical manufacturing based on ERP systems and artificial intelligence tools for data analysis and process management.
Innovative technological solutions were also presented by Anton Bulakin, who spoke about the use of microfluidic technologies to obtain new dosage forms and synthesize nanoparticles. Elizaveta Surbeeva presented the results of technology transfer for obtaining purified polysaccharides from Apium graveolens L. for the pharmaceutical and food industries.
Prospects for the development of lipid nanoparticles for mRNA delivery were outlined by Ksenia Zarifi. Practice-oriented research continued with Sergey Malkov, who presented the development of hemostatic drug sponges, and Murtuzali Gadayev, who examined bilayer osmotic systems for prolonged release of anti-inflammatory substances.
Summing up, the moderators noted the high interest of the professional community in the section and the productive combination of academic research and industrial solutions. The reports of graduate students and business representatives formed a unified discussion platform aimed at further technological development of the pharmaceutical industry.
Opening the discussion, Alexey Yarutkin presented the development directions of the XV edition of the State Pharmacopoeia, emphasizing the role of standardization of dosage forms and excipients in ensuring drug quality. The topic was continued by Karen Sakanyan, who examined approaches to assessing the quality of pharmaceutical substances used as auxiliary components.
Practical aspects of manufacturing processes were revealed by Victor Kirilenko (Akademlab LLC), who noted the advantages of engaging independent organizations in validation and qualification: increased objectivity of assessment, reduced regulatory risks, and optimization of enterprise costs.
Promising technological media were the subject of Alexander Shikov's presentation, who introduced natural deep eutectic solvents as an environmentally safe alternative to traditional solvents. Despite a relatively short period of application, this direction is actively developing and opens up broad opportunities for further research.
Issues of controlled drug release were examined by Alexey Marchenko using alginate microcapsules as an example. The presented results showed the influence of technological parameters on shell structure and release profile, including successful models of probiotic microorganism encapsulation.
The experience of interaction between science and industry was presented by Sergey Belokurov, who described the development of urological dietary supplements in a "university – industrial partner – state" collaboration format. The importance of grant support as a tool for bringing developments to practical application was noted.
Modern approaches to active substance delivery were discussed in a report by Darya Gordeeva on intranasal systems for transporting drug substances to the brain. The theme of innovative carriers was continued by Ilya Sheferov, who presented research on transfersomal systems with 5-fluorouracil and cerium oxide nanoparticles.
Digital transformation of the industry was highlighted by Igor Simonenko, who presented a model of the digital architecture of pharmaceutical manufacturing based on ERP systems and artificial intelligence tools for data analysis and process management.
Innovative technological solutions were also presented by Anton Bulakin, who spoke about the use of microfluidic technologies to obtain new dosage forms and synthesize nanoparticles. Elizaveta Surbeeva presented the results of technology transfer for obtaining purified polysaccharides from Apium graveolens L. for the pharmaceutical and food industries.
Prospects for the development of lipid nanoparticles for mRNA delivery were outlined by Ksenia Zarifi. Practice-oriented research continued with Sergey Malkov, who presented the development of hemostatic drug sponges, and Murtuzali Gadayev, who examined bilayer osmotic systems for prolonged release of anti-inflammatory substances.
Summing up, the moderators noted the high interest of the professional community in the section and the productive combination of academic research and industrial solutions. The reports of graduate students and business representatives formed a unified discussion platform aimed at further technological development of the pharmaceutical industry.